Compartmentalized signalling: Ras proteins and signalling nanoclusters
作者： Jasminka Omerovic , Ian A. Prior
DOI: 10.1111/J.1742-4658.2009.06928.X
关键词:
摘要: Differential subcellular compartmentalization of the three main Ras isoforms (H-Ras, N-Ras and K-Ras) is believed to underlie their biological differences. Modulatable interactions between cellular membranes C-terminal hypervariable region motifs determine differences in trafficking relative proportions each isoform cell-surface signalling nanoclusters intracellular endoplasmic reticulum/Golgi, endosomal mitochondrial compartments. regulators, effectors scaffolds are also differentially distributed, potentially enabling preferential coupling specific pathways location. Here we summarize mechanisms underlying compartment-specific outputs generated.
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