Liver and peripheral blood concentration ratio (L/P) as a marker of postmortem drug redistribution: a literature review

摘要: The liver to peripheral blood (L/P) ratio, based upon review of previously published works, was evaluated as a marker postmortem redistribution (PMR). Literature supported the proposed model that drugs exhibiting an L/P ratio less than 5 are prone little or no PMR, while those with greater 20-30 have propensity for significant redistribution. Many antidepressants, including both tricyclic antidepressants and selective serotonin re-uptake inhibitors, were markedly differentiated from verified be free from, exhibit little, PMR. magnitude concentrations also appeared provide advantage over conventional central PMR by demonstrating wide range values (1.6-97) interpretation drugs' potential for, variations in,