Contractile dysfunction of "reperfused" neonatal rat heart cells: a model for studying "myocardial stunning" at the cellular level?
作者： Peter Boekstegers , Alexander Pfeifer , Wolfgang Peter , Karl Werdan
DOI: 10.1007/978-1-4615-3428-0_68
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摘要: Myocardial stunning defined by prolonged contractile dysfunction of reperfused hearts after ischemia (Braunwald et al. 1982) was demonstrated both in vivo and isolated heart models such as the Langendorff preparation. Evidence exists that different mechanisms (e.g. oxygen radicals, “no reflow” phenomenon, calcium overload) cells (endothelial cells, leukocytes, cardiomyocytes) (Bolli 1990, Marban 1991, Lefer Bagchi 1990) are involved development myocardial stunning. However, contribution each to finally observed cardiomyocyte is not clear 1990). Intact heart, which cell types present, do allow differentiation between mediated injury susceptibility itself
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