Previously known and newly diagnosed atrial fibrillation: a major risk indicator after a myocardial infarction complicated by heart failure or left ventricular dysfunction.

摘要: Aims To characterize the relationship between known and newly diagnosed atrial fibrillation (AF) risk of death major cardiovascular (CV) events in patients with acute myocardial infarction (MI) complicated by heart failure (HF) and/or left ventricular systolic dysfunction (LVSD). Methods The VALIANT trial enrolled 14,703 individuals MI HF LVSD. AF was assessed at presentation randomization (median 4.9 days after symptom onset). Primary outcomes were CV 3 years following MI. Results A total 1812 current (AF randomization), 339 prior (history without AF), 12,509 enrolled. Patients older; had more HF, angina, MI, received beta-blockers thrombolytics less often than those AF. Three-year mortality estimates 20% AF, 37% 38% Compared multivariable adjusted HR 1.25 (1.03–1.52; p = 0.03) for 1.32 (1.20–1.45; < 0.0001) 1.15 (0.98–1.35; 0.08) 1.21 (1.12–1.31; 0.0001). Conclusion AF is associated greater long-term adverse or