Morphological basis of sensory neuropathy and neuroimmunomodulation in minor salivary glands of patients with Sjögren's syndrome.

摘要: Abstract Objective: A predominance of sensory neuropathy was earlier described in Sjogren’s syndrome (SS), which might precede the presence sicca symptoms. The mechanism SS is unknown. Therefore, aim this study to determine quantitative changes different neuropeptide containing nerve terminals and immunocompetent cells labial salivary glands primary SS. Design: Immunohisto- immunocytochemical methods were used for detection immunoreactive (IR) elements data compared with healthy controls. Results: All investigated IR fibres found quantity localisation both control glands. density them changed variously number substance P (SP), Y (NPY) (P