Hybrid antibacterial peptide based on FV7 anti-bio-membrane, preparation method and application thereof

摘要: The invention relates to a hybrid antibacterial peptide based on an FV7 anti-bio-membrane, and preparation method application thereof. sequence of the is represented as SEQ ID No.1. According main physical chemical parameters structural functional relationship original peptide, anti-bio-membrane fragment active centre LL natural LL-37 are synthesized through obtain FV-LL. Through series in-vitro test, activities peptides FV-LL verified, comparison, it found that greatly improved in activity also has activity, so hybridization, can be improved, thereby improving cell selectivity. Furthermore, mechanism providing theoretical basis for peptide.