Incidence of cancer and mortality among employees in the asbestos cement industry in Denmark.

摘要: In a cohort study of the incidence cancer and mortality among 7996 men 584 women employed in Danish asbestos cement industry between 1928 1984 over 99% were traced. Chrysotile was only fibre type used until 1946, when amosite (in 1952) crocidolite also introduced. constituted 89%, 10%, 1% used. During first 25 years manufacture exposure levels high, especially areas where handled dry. Measurements from 1948 indicate that may have ranged 100 to 1600 times present threshold limit value 0.5 fibre/ml. 1973 more than 41% personal samples higher 2 f/ml. About 76% workforce left factory within five starting employment. A total 1346 deaths 612 cases observed 1943 1984. Among overall (O/E 1.18; 95% CI 1.12-1.25), 1.32; 1.19-1.46), 1.22; 1.12-1.32) significantly increased compared with all men. This not so women. For men, significant excess risks found for lung 1.80; 1.54-2.10), pleura 5.46; 2.62-10.05), mediastinum 5.00; 1.01-14.61), stomach 1.43; 1.03-1.93), other male genital organs 3.03; 1.11-6.60). The non-malignant pulmonary diseases 1.63; 1.33-1.98). group workers employment 1928-40 an risk laryngeal 5.50;95% 1.77-12.82). 12 pleural one peritoneal mesotheliomas original notification forms reviewed patients cohort.