Effects of fowlpox virus infection on lipid metabolism in cultured chicken embryo cells.

摘要: Lipid biosynthesis was measured in cultured chicken embryo cells after infection with fowlpox virus. Between 24 and 72 h postinfection, virus-infected incorporated less [14C]acetate 3H2O into fatty acids sterols than did mock-infected cells, demonstrating a virus-dependent inhibition of general lipid metabolism. Two specific effects virus were an accumulation C-4 alkylated sterol intermediates monounsaturated acid biosynthesis.