Nephroprotective effect of bee honey and royal jelly against subchronic cisplatin toxicity in rats
作者： Abdelazim Ibrahim , Mabrouk A. Abd Eldaim , Mohamed M. Abdel-Daim
DOI: 10.1007/S10616-015-9860-2
关键词:
摘要: Cisplatin is one of the most potent and effective chemotherapeutic agents. However, its antineoplastic use limited due to cumulative nephrotoxic side effects. Therefore, present study was undertaken examine nephroprotective potential dietary bee honey royal jelly against subchronic cisplatin toxicity in rats. Male Wistar rats were randomly divided into controls, cisplatin-treated, honey-pretreated cisplatin-treated jelly-pretreated groups. Bee given orally at doses 20 100 mg/kg, respectively. Subchronic induced by (1 mg/kg bw, ip), twice weekly for 10 weeks. treated animals revealed a significant increase serum level renal injury products (urea, creatinine uric acid). Histopathologically, produced pronounced tubulointerstitial injuries, upregulated fibrogenic factors, α-smooth muscle actin (α-SMA) transforming growth factor β1(TGF-β1), downregulated cell proliferation marker, bromodeoxyuridine (Brdu). Dietary normalized elevated product biomarkers, improved histopathologic changes, reduced expression α-SMA TGF-β1 increased Brdu. it could be concluded that honey, used as preventive natural cisplatin-induced injury.
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sci-hub.se 参考文章(46)
Man Jiang, Zheng Dong, Regulation and pathological role of p53 in cisplatin nephrotoxicity. Journal of Pharmacology and Experimental Therapeutics. ,vol. 327, pp. 300- 307 ,(2008) , 10.1124/JPET.108.139162
Erejuwa O. Omotayo, Sunil Gurtu, Siti Amrah Sulaiman, Mohd Suhaimi Ab Wahab, Sirajudeen K.N.S, Md. Salzihan Md. Salleh, Hypoglycemic and antioxidant effects of honey supplementation in streptozotocin-induced diabetic rats. International Journal for Vitamin and Nutrition Research. ,vol. 80, pp. 74- 82 ,(2010) , 10.1024/0300-9831/A000008
M.S. Razzaque, A. Kumatori, T. Harada, T. Taguchi, Coexpression of Collagens and Collagen-Binding Heat Shock Protein 47 in Human Diabetic Nephropathy and IgA Nephropathy Nephron. ,vol. 80, pp. 434- 443 ,(1998) , 10.1159/000045217
Takashi Taguchi, Arifa Nazneen, M. Ruhul Abid, Mohammed S. Razzaque, Cisplatin-Associated Nephrotoxicity and Pathological Events Contributions To Nephrology. ,vol. 148, pp. 107- 121 ,(2005) , 10.1159/000086055
Sibel Silici, Oguz Ekmekcioglu, Gokhan Eraslan, Abdullah Demirtas, Antioxidative effect of royal jelly in cisplatin-induced testes damage. Urology. ,vol. 74, pp. 545- 551 ,(2009) , 10.1016/J.UROLOGY.2009.05.024
Mohamed M Abdel-Daim, Mabrouk A Abd Eldaim, Mohamed M Mahmoud, None, Trigonella foenum-graecum protection against deltamethrin-induced toxic effects on haematological, biochemical, and oxidative stress parameters in rats. Canadian Journal of Physiology and Pharmacology. ,vol. 92, pp. 679- 685 ,(2014) , 10.1139/CJPP-2014-0144
M. Kuhlmann, G. Burkhardt, H. Kohler, Insights into potential cellular mechanisms of cisplatin nephrotoxicity and their clinical application. Nephrology Dialysis Transplantation. ,vol. 12, pp. 2478- 2480 ,(1997) , 10.1093/NDT/12.12.2478
Reem M Galal, Hala F Zaki, EL NASR MONA M SEIF, Azza M Agha, None, Potential Protective Effect of Honey Against Paracetamol-induced Hepatotoxicity Archives of Iranian Medicine. ,vol. 15, pp. 674- 680 ,(2012)
Masaki Kamakura, Tatsuya Moriyama, Toshiyuki Sakaki, Changes in hepatic gene expression associated with the hypocholesterolaemic activity of royal jelly Journal of Pharmacy and Pharmacology. ,vol. 58, pp. 1683- 1689 ,(2010) , 10.1211/JPP.58.12.0017
Mohamed M. Abdel-Daim, Pharmacodynamic interaction of Spirulina platensis with erythromycin in Egyptian Baladi bucks (Capra hircus) Small Ruminant Research. ,vol. 120, pp. 234- 241 ,(2014) , 10.1016/J.SMALLRUMRES.2014.05.013