CD4 + /CD8 + mucosa-associated invariant T cells foster the development of endometriosis: a pilot study

摘要: Immune dysregulation is one of the mechanisms to promote endometriosis (EMS). Various T cell subpopulations have been reported play different roles in development EMS. The mucosa-associated invariant (MAIT) an important subset pathogenesis various autoimmune diseases. Evidence has indicated that there are three functionally distinct MAIT subsets: CD4+, CD8+ and CD4/CD8−/− (double negative, DN) cells. Till now, associations between not studied. Our research investigates peripheral blood (PB) peritoneal fluid (PF) from EMS patients. Thirty-two patients eighteen controls were included. PB PF collected. Tests cytokines plasma performed by ELISA kit. Characterisations done flow cytometry. cells defined as CD3 + CD161 + Vα7.2+ Based on CD4 CD8 expression, they divided into CD8+MAIT, CD4+MAIT DN MAIT. Enrichments cells, especially subsets found. Moreover, had a high activation group. produced higher level IL-8/12/17 compared these controls. On contrary, control exhibited impressive upregulation however, showed expression PD-1. Lastly, we relevance analysis, discovered accumulation positively correlated with elevated serum CA125 production These results suggest progression endometriosis.