Histomorphometric analysis of rat skeleton following spaceflight

摘要: Male Sprague-Dawley rats were placed in orbit for 7 days aboard the space shuttle. Bone histomorphometry was performed long bones and lumbar vertebrae of flight compared with data derived from ground-based control rats. Trabecular bone mass not altered during 1st wk weightlessness. Strong trends observed decreased periosteal formation tibial diaphysis, reduced osteoblast size proximal tibia, surface number vertebra. For most part, histological indexes resorption normal The results indicate that weightlessness are sufficient duration to induce histologically detectable loss trabecular However, cortical appear be diminished spaceflight.