Chapter 29 Microneurography in the assessment of neuropathic pain.

摘要: Publisher Summary This chapter describes microneurography as a neurophysiological method that allows microelectrode recordings of impulses in single nerve fibers awake human subjects. It has been employed for from afferent sensory fibers, efferent sympathetic and proprioceptive fibers. discusses experiments experimental models pain/neuropathic pain shed important light on pathophysiological mechanisms involved primary secondary hyperalgesia. The reviews the principal findings nociceptive systems relevance pathology. also provides future perspective microneurography. As does not allow recording directly endings or membrane potential, molecular transduction cannot be investigated directly. time course post-excitatory hyperpolarization can assessed by and, thus, there is an exciting to finally bridge gap between cellular systemic approach. Despite many limitations microneurographic approach unique data healthy subjects patients mediative position clinical science basic research.