Electroencephalographic investigation in rabbits of drugs acting at GABA- benzodiazepine-barbiturate/picrotoxin receptors complex

摘要: This paper describes the EEG profiles, observed in rabbits, of drugs which affect GABA synaptic activity by acting at GBB complex. Drugs enhance induce sedation associated with synchronization. However, muscimol, THIP, GHB and baclofen signs CNS stimulation (light tremors forelimbs, chewing, light nystagmus hyperpnea) spikes. Signs (chewing jerks head) also occur after BDZs barbiturates, are presence 12–24 20–25 Hz waves, respectively. reduce (bicuculline, inverse BDZ agonists, PTZ, picrotoxin Ro 5-3663) three dose-dependent stages changes: trains slow spike-and-wave complexes paroxysmal rostral encephalic structures without apparent changes electrical spinal cord. The first two a behavioral state alert third stage tonico-clonic convulsions. Among DMCM β-CCM elicit all stages, whereas FG 7142 β-CCE only CGS 8216 first. antagonists 15-1788 15-3505 (0.2–30 mg/kg IV) do not significantly pattern. they selectively inhibit effects diazepam agonists. In both cases, inhibition is doses as low 0.2 IV leads to an desynchronization. possible involvement modifications etiology petit mal grand epilepsies discussed.