Functional analysis of mononuclear cells infiltrating into tumors: differential cytotoxicity of mononuclear cells from tumors of immune and nonimmune rats.

摘要: A million syngeneic gliosarcoma (T-9) cells injected subcutaneously are sufficient to kill Fisher rats within 2 mo. became resistant T-9 by surgical removal of the implanted tumor and repeated immunization with MMC-treated cells. Histopathologic studies revealed massive accumulation mononuclear in tissues immune that were rejecting tumors, whereas very few found nonimmune rats. Cell populations infiltrating into identified immunohistochemical techniques. Mononuclear regressing tumors mostly be T cells, two-thirds these OX-8 positive. In contrast, growing mixtures macrophages positive found. isolated from determine whether lysed specifically. Significant tumoricidal activity was seen when used, no detectable observed Winn assays confirmed vitro 51Cr release showing rejected only normal along