Muscle regeneration and fiber‐type transformation during distraction osteogenesis

摘要: The successful outcome of distraction osteogenesis depends in part on the adequate adaptation surrounding soft tissue. We characterized tibialis anterior during at different rates (0.7 and 1.4 mm/day) amounts (15 30%) lengthening. documented increased expression neonatal slow myosin heavy chain skeletally immature rabbits. There was neither experimental soleus or muscle fibers nor gastrocnemius. amount concentrated distal half muscle, whereas increase number that were labeled with antibodies to occurred same extent throughout anterior. Electrophysiological methods showed functionally intact after osteogenesis. concluded young, animals, seems induce a recapitulation developmental process without leading functional changes. In addition, osteogenesis, fiber-type transformation occurs similar observed models overloading.