ANTIGEN-SPECIFIC MEMORY B CELL DEVELOPMENT

摘要: ▪ Abstract Helper T (Th) cell–regulated B cell immunity progresses in an ordered cascade of cellular development that culminates the production antigen-specific memory cells. The recognition peptide MHC class II complexes on activated antigen-presenting cells is critical for effective Th selection, clonal expansion, and effector function (Phase I). Cognate cell–B interactions then promote either short-lived plasma (PCs) or germinal centers (GCs) II). These GCs expand, diversify, select high-affinity variants entry into long-lived compartment III). Upon antigen rechallenge, rapidly expand differentiate PCs under cognate control IV). We review molecular regulators this dynamic process with emphasis multiple fates develop vivo.