Evaluation of a patient self-directed mealtime insulin titration algorithm: a US payer perspective

摘要: Objective To model the potential economic impact of implementing AUTONOMY once daily (Q1D) patient self-titration mealtime insulin dosing algorithm vs standard care (SOC) among a population patients with Type 2 diabetes living in US. Methods Three validated models were used this analysis: The Treatment Transitions Model (TTM) was to generate primary results, while both Archimedes (AM) and IMS Core Diabetes Models (IMS) test veracity results produced by TTM. data from 'real world' representative sample (2012 US National Health Nutrition Examination Survey) that matched characteristics enrolled randomized controlled trial 'AUTONOMY' cohort. base-case time horizon 10 years. Results modeling TTM demonstrated total costs reduced $1732, savings predicted occur as early year 1. three consistent, showing reduction for all sensitivity analyses. Limitations Data short-term clinical trials develop long-term projections. nature such extrapolation leads increased uncertainty. Conclusion indicate Q1D has abate first year.