Randomized Controlled Trial of Mycobacterium vaccae Immunotherapy in Non-Human Immunodeficiency Virus-Infected Ugandan Adults with Newly Diagnosed Pulmonary Tuberculosis
作者： John L Johnson , R Moses Kamya , Alphonse Okwera , Anita M Loughlin , Sam Nyole
DOI: 10.1086/315393
关键词:
摘要: Adjunctive immunotherapy with heat-killed Mycobacterium vaccae was studied in a randomized, placebo-controlled trial of 120 non-human immunodeficiency virus-infected adults newly diagnosed pulmonary tuberculosis. Patients were randomized to single dose M. or placebo 1 week after beginning chemotherapy and followed up for year. safe well tolerated. The rate sputum culture conversion month tuberculosis treatment 35% the group only 14% (P = .01) but comparable at 2 months thereafter. receiving had greater improvement on chest radiography 6 (91% vs. 77% recipients; P .04) 12 (94% 80%; initiation treatment. These data provide evidence an early increase radiographic among patients who received vaccae. Further studies are warranted.
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