Ischemia-Induced Shift of Inhibitory and Excitatory Amino Acids from Intra- to Extracellular Compartments

摘要: Brain ischemia was induced for 10 or 30 min by clamping the common carotid arteries in rabbits whose vertebral had previously been electrocauterized. EEG and tissue content of high energy phosphates were used to verify ischemic state evaluate degree postischemic recovery. Extracellular levels total contents amino acids followed hippocampus during 4 h recirculation. At end a 30-min period, GABA increased 250 times, glutamate 160 aspartate taurine times extracellular phase. The returned normal within reflow. A delayed increase phosphoethanolamine ethanolamine peaked after 1–2 Ten minutes elicited considerably smaller but similar effects. With respect hippocampus, decreased 30–50% control while appeared unaffected Alanine, valine, phenylalanine, leucine, a...