New isopimarane diterpenes and nortriterpene with cytotoxic activity from Ephorbia alatavica Boiss
作者： Rushangul Rozimamat , Rui Hu , Haji Akber Aisa
DOI: 10.1016/J.FITOTE.2018.02.026
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摘要: Abstract Three new isopimarane diterpenes and one nor-triterpenes, along with five known were isolated from the whole areal part of Ephorbia alatavica Boiss. The structures compounds (1–4) determined based on extensive spectroscopic analysis, including HR-ESIMS, 1D 2D NMR data. A plausible biosynthetic pathway for hypothesized. All screen cytotoxicity activity against MCF-8, HeLa A549 cell lines in vitro by MTT assay. New compound 1 9 showed potential cytotoxic activities IC50 values 15.327 μg/mL, 23.066 μg/mL MCF-8 lines, compound1 noteworthy 13.033 μg/mL cancer line. 2, 4 moderate three human value around 50 μg/mL, which compared positive control doxorubicin (DOX).
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