A Comparison of Flow-mediated Dilatation and Peripheral Artery Tonometry for Measurement of Endothelial Function in Healthy Individuals and Patients with Peripheral Arterial Disease

作者: R.B. Allan , C.L. Delaney , M.D. Miller , J.I. Spark

DOI: 10.1016/J.EJVS.2012.12.002

关键词:

摘要: Objective Flow-mediated dilatation (FMD) and peripheral artery tonometry (PAT) are commonly used methods for assessing endothelial function in a research setting but it is unclear how well they correlate. This study aimed to compare correlate these patients with arterial disease (PAD) healthy individuals. Materials FMD PAT measurements were obtained as samples of convenience from 26 PAD 25 subjects. was defined the percentage increase brachial diameter after distal occlusion measured using reactive hyperaemia index (RHI). Results Patients had significantly lower than subjects (2.43% vs. 5.80%, p r  = 0.284,  = 0.160), (  = 0.153,  = 0.464) or when both groups combined  = 0.174,  = 0.22). Conclusion The lack change RHI suggests that not sensitive measure function. correlation interchangeable. should be substitute

参考文章(38)
Mary C Corretti, Todd J Anderson, Emelia J Benjamin, David Celermajer, Francois Charbonneau, Mark A Creager, John Deanfield, Helmut Drexler, Marie Gerhard-Herman, David Herrington, Patrick Vallance, Joseph Vita, Robert Vogel, Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: A report of the International Brachial Artery Reactivity Task Force Journal of the American College of Cardiology. ,vol. 39, pp. 257- 265 ,(2002) , 10.1016/S0735-1097(01)01746-6
John E. Deanfield, Julian P. Halcox, Ton J. Rabelink, Endothelial Function and Dysfunction Testing and Clinical Relevance Circulation. ,vol. 115, pp. 1285- 1295 ,(2007) , 10.1161/CIRCULATIONAHA.106.652859
Karen L. BERRY, R. Andrew P. SKYRME-JONES, Ian T. MEREDITH, Occlusion cuff position is an important determinant of the time course and magnitude of human brachial artery flow-mediated dilation Clinical Science. ,vol. 99, pp. 261- 267 ,(2000) , 10.1042/CS0990261
K. M. Dickinson, P. M. Clifton, J. B. Keogh, Endothelial function is impaired after a high-salt meal in healthy subjects The American Journal of Clinical Nutrition. ,vol. 93, pp. 500- 505 ,(2011) , 10.3945/AJCN.110.006155
M.F. Meyer, D. Lieps, H. Schatz, M. Pfohl, Impaired flow-mediated vasodilation in type 2 diabetes: Lack of relation to microvascular dysfunction Microvascular Research. ,vol. 76, pp. 61- 65 ,(2008) , 10.1016/J.MVR.2008.03.001
Naomi M. Hamburg, Joseph Palmisano, Martin G. Larson, Lisa M. Sullivan, Birgitta T. Lehman, Ramachandran S. Vasan, Daniel Levy, Gary F. Mitchell, Joseph A. Vita, Emelia J. Benjamin, Relation of brachial and digital measures of vascular function in the community: the Framingham heart study. Hypertension. ,vol. 57, pp. 390- 396 ,(2011) , 10.1161/HYPERTENSIONAHA.110.160812
Elif Seda Selamet Tierney, Jane W Newburger, Kimberlee Gauvreau, Judith Geva, Elizabeth Coogan, Steven D Colan, Sarah D de Ferranti, None, Endothelial Pulse Amplitude Testing: Feasibility and Reproducibility in Adolescents The Journal of Pediatrics. ,vol. 154, pp. 901- 905 ,(2009) , 10.1016/J.JPEDS.2008.12.028
Sagar N. DOSHI, Katerina K. NAKA, Nicola PAYNE, Christopher J.H. JONES, Moira ASHTON, Malcolm J. LEWIS, Jonathan GOODFELLOW, Flow-mediated dilatation following wrist and upper arm occlusion in humans: the contribution of nitric oxide. Clinical Science. ,vol. 101, pp. 629- 635 ,(2001) , 10.1042/CS1010629
Emelia J. Benjamin, Martin G. Larson, Michelle J. Keyes, Gary F. Mitchell, Ramachandran S. Vasan, John F. Keaney, Birgitta T. Lehman, Shuxia Fan, Ewa Osypiuk, Joseph A. Vita, Clinical Correlates and Heritability of Flow-Mediated Dilation in the Community The Framingham Heart Study Circulation. ,vol. 109, pp. 613- 619 ,(2004) , 10.1161/01.CIR.0000112565.60887.1E