Impaired flow-mediated vasodilation in type 2 diabetes: Lack of relation to microvascular dysfunction

摘要: A reduced availability of nitric oxide (NO) is an important feature endothelial dysfunction occurring early in the course type 2 diabetes. The measurement flow-mediated dilation (FMD) brachial artery after forearm ischemia supposed to be a non-invasive method assess production and release NO. impairment reactive hyperemia due microvascular diabetes might cause insufficient increase shear stress stimulating NO release, thus leading underestimation FMD. Therefore, aim present study was investigate relationship between microcirculatory disturbances FMD diabetic patients. 63 patients 44 non-diabetic control subjects were investigated. Capillary blood cell velocity (CBV) assessed at dorsal middle phalangeal area left ring finger. Lumen diameter measured by high-resolution ultrasound. Patients investigated rest 5-min suprasystolic arterial compression. Percentage change CBV during (CBV%) (FMD%) relative baseline calculated. CBV% (63.4+/-10.7% vs. 124.0+/-18.5%; p<0.01) FMD% (3.8+/-0.8% 6.9+/-0.9%; compared their subjects. not related (r=0.14; p=0.139). lack association reduction endothelium-dependent vasodilation postocclusive observed contradicts assumption that only consequence impaired dysfunction. It also lends support suggestion conduit vessels cutaneous responses least partly develop independently several differences pathogenesis.