Long-term persistence of immunity to hepatitis B after vaccination during infancy in a country where endemicity is low.

摘要: Background. The long-term response to hepatitis B vaccination during infancy has not been fully evaluated in countries where endemicity is low. Methods. present study was a serological investigation of immunity adolescence. In cohort children who were born virus carrier mothers and vaccinated infancy, evidence past or current infection the single booster dose vaccine analyzed. Sixty-four whose antibody levels measured after immunization (group 1) 52 younger siblings did undergo postvaccination tests 2) studied. Results. One child each group showed natural infection. 1, 32 (50%) had undetectable surface antigen (anti-HBs), only 8 (13%) >100 mIU/mL. After vaccine, 7 (11%) still anti-HBs, 3 (5%) primary response, 50 (78%) Five nonresponders all responders also received B-specific immunoglobulin (HBIG) at birth. 2 similar but with slightly higher anti-HBs. Conclusions. Most birth retain immunological memory for 15 years, those more likely have HBIG birth, suggesting that passive may interfere induction memory.