Regioselective synthesis of deuterated analogs of the neurotoxin MPTP
作者： Stéphane Mabic , Neal Castagnoli
DOI: 10.1002/(SICI)1099-1344(199603)38:3<255::AID-JLCR835>3.0.CO;2-0
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摘要: 1-Methyl-4-phenyl-2-pyridone has been used as starting material for the efficient and regioselective synthesis of deuterated analogues neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). MPTP-2,2-d 2 , MPTP-6,6-d MPTP-2,2,6,6-d 4 were obtained in good yield through a combination alkaline deuterium exchange selective LiAlH LiAlD reduction reactions.
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