Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase.
作者： Kan Chiba , Anthony Trevor , Neal Castagnoli
DOI: 10.1016/0006-291X(84)91293-2
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摘要: The neurotoxic chemical MPTP (1-methyl-4-phenyl-1,2,4,5-tetrahydropyridine) is metabolized by rat brain mitochondrial fractions at a rate of 0.91 +/- 0.02 nmoles/mg protein/min. major metabolite has been identified as the 1-methyl-4- phenylpyridinium species. This biotransformation process blocked 10(-7) M deprenyl and pargyline. itself inhibited metabolism benzylamine fractions. These results are discussed in terms possible bioactivation mechanisms that may be associated with neurodegenerative properties .
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sci-hub.se 参考文章(10)
Celia White Tabor, Herbert Tabor, Sanford M. Rosenthal, PURIFICATION OF AMINE OXIDASE FROM BEEF PLASMA Journal of Biological Chemistry. ,vol. 208, pp. 645- 661 ,(1954) , 10.1016/S0021-9258(18)65591-7
J. Langston, P Ballard, J. Tetrud, I Irwin, Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis Science. ,vol. 219, pp. 979- 980 ,(1983) , 10.1126/SCIENCE.6823561
Trong Lang Nguyen, Larry D. Gruenke, Neal Castagnoli, Metabolic oxidation of nicotine to chemically reactive intermediates. Journal of Medicinal Chemistry. ,vol. 22, pp. 259- 263 ,(1979) , 10.1021/JM00189A008
R. J. Crutchley, A. B. P. Lever, Ruthenium(II) tris(bipyrazyl) dication: a new photocatalyst Journal of the American Chemical Society. ,vol. 102, pp. 7128- 7129 ,(1980) , 10.1021/JA00543A053
Richard B. Silverman, Stephen J. Hoffman, Mechanism of inactivation of mitochondrial monoamine oxidase by N-cyclopropyl-N-arylalkyl amines Journal of the American Chemical Society. ,vol. 102, pp. 884- 886 ,(1980) , 10.1021/JA00522A093
Doyle G. Graham, Sylvia M. Tiffany, William R. Bell, William F. Gutknecht, Autoxidation versus covalent binding of quinones as the mechanism of toxicity of dopamine, 6-hydroxydopamine, and related compounds toward C1300 neuroblastoma cells in vitro. Molecular Pharmacology. ,vol. 14, pp. 644- 653 ,(1978)
Georgina Rodriguez De Lores Arnaiz, Martha Alberici, Eduardo De Robertis, Ultrastructural and enzymic studies of cholinergic and non-cholinergic synaptic membranes isolated from brain cortex. Journal of Neurochemistry. ,vol. 14, pp. 215- 225 ,(1967) , 10.1111/J.1471-4159.1967.TB05897.X
E. S. Vesell, B. H. Dvorchik, M. P. Marietta, Judith Weisz, R. D. Hartman, Characterization of cytochrome P-450-dependent aminopyrine N-demethylase in rat brain: comparison with hepatic aminopyrine N-demethylation. Journal of Pharmacology and Experimental Therapeutics. ,vol. 208, pp. 271- 279 ,(1979)
D J Smith, A J Azzaro, K T Demarest, The presence of the type A form of monoamine oxidase within nigrostriatal dopamine-containing neurons. Journal of Pharmacology and Experimental Therapeutics. ,vol. 215, pp. 461- 468 ,(1980)
Chronic parkinsonism secondary to intranasal administration of a product of meperidine-analogue synthesis. The New England Journal of Medicine. ,vol. 310, pp. 325- 325 ,(1984) , 10.1056/NEJM198402023100520