Reduced Striatal [3H]Inositol 1,4,5‐Trisphosphate Binding in Huntington's Disease
作者： Jerry J. Warsh , Jeffrey M. Politsky , Peter P. Li , Stephen J. Kish , O. Hornykiewicz
DOI: 10.1111/J.1471-4159.1991.TB11440.X
关键词:
摘要: : Specific [3H]inositol 1,4,5-trisphosphate ([3H]InsP3) binding was studied in regions of postmortem brain from 15 patients with Huntington's disease (HD) and 13 nonneurological controls. Single-point analyses, using 5.0 nM InsP3, showed statistically significant reductions specific [3H]InsP3 the caudate (–71%) putamen (–75%) HD compared Frontal occipital cortical not significantly different between controls, a finding suggesting that reduced parallels regional specificity neuropathological changes HD. Scatchard analyses data competition assays performed on nucleus revealed found single-point were due to decrease both density (–57%) affinity (–50%) The concomitant InsP3 receptor suggest these alterations may be produced by processes addition cell loss. These results possibility disturbances function, possibly resulting altered intracellular calcium flux homeostasis, occur participate pathogenesis this neurodegenerative disorder.
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