[3H]Inositol 1,4,5-trisphosphate binding in human cerebral cortex
作者： L.Trevor Young , Peter P. Li , Stephen J. Kish , Andrew S. Chiu , Jerry J. Warsh
DOI: 10.1016/0304-3940(88)90462-4
关键词:
摘要: Abstract Specific, saturable and reversible binding of [ 3 H]inositol 1,4,5-trisphosphate (IP ) was demonstrated to membranes prepared from autopsied cerebral cortices 6 subjects who were free psychiatric or neurological disease. The has an affinity 27 ± 8 nM (mean S.E.M.); capacity ( B max 1.09 0.18 pmol/mg protein is in the presence excess unlabelled IP . These H]IP sites are likely be physiologically significant receptors which merit further characterization normal diseased human brain.
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