Cerebellar [3H]inositol 1,4,5-trisphosphate binding is markedly decreased in human olivopontocerebellar atrophy.
作者： Stephen J. Kish , Peter P. Li , Yves Robitaille , Robert Currier , Joseph Gilbert
DOI: 10.1016/0006-8993(89)90874-3
关键词:
摘要: We examined the behaviour of [3H]inositol-1,4,5-trisphosphate (IP3) binding in autopsied cerebellar and cerebral cortex 10 neurologically normal controls 8 patients with end-stage olivopontocerebellar atrophy (OPCA), a ataxia disorder characterized histologically by severe degeneration Purkinje cells. [3H]IP3 to human was 6-15 times higher than cortex. As compared controls, mean markedly reduced 61% OPCA whereas levels were frontal occipital cortices. Since cell dendrite receives neuronal input from granule cells climbing fibers utilizing glutamate aspartate, respectively, as neurotransmitters, IP3 may reflect loss containing these excitatory amino acid receptors linked phosphatidylinositide second messenger system. Our data suggest that humans, be highly localized dendrite.
elsevier.com
sci-hub.se 参考文章(22)
F Nicoletti, JT Wroblewski, A Novelli, H Alho, A Guidotti, E Costa, The activation of inositol phospholipid metabolism as a signal-transducing system for excitatory amino acids in primary cultures of cerebellar granule cells. The Journal of Neuroscience. ,vol. 6, pp. 1905- 1911 ,(1986) , 10.1523/JNEUROSCI.06-07-01905.1986
R. D. Currier, G. Glover, J. F. Jackson, A. C. Tipton, Spinocerebellar ataxia: Study of a large kindred: I. General information and genetics Neurology. ,vol. 22, pp. 1040- 1040 ,(1972) , 10.1212/WNL.22.9.1040
JOHN W. SCHUT, HEREDITARY ATAXIA Archives of Neurology & Psychiatry. ,vol. 63, pp. 535- 568 ,(1950) , 10.1001/ARCHNEURPSYC.1950.02310220002001
L.Trevor Young, Peter P. Li, Stephen J. Kish, Andrew S. Chiu, Jerry J. Warsh, [3H]Inositol 1,4,5-trisphosphate binding in human cerebral cortex Neuroscience Letters. ,vol. 87, pp. 283- 287 ,(1988) , 10.1016/0304-3940(88)90462-4
L Wiklund, G Toggenburger, M Cuenod, Aspartate: possible neurotransmitter in cerebellar climbing fibers Science. ,vol. 216, pp. 78- 80 ,(1982) , 10.1126/SCIENCE.6121375
Stefan R. Nahorski, David A. Kendall, Ian Batty, Receptors and phosphoinositide metabolism in the central nervous system. Biochemical Pharmacology. ,vol. 35, pp. 2447- 2453 ,(1986) , 10.1016/0006-2952(86)90038-9
Thomas L. Smith, Chronic ethanol consumption reduces [3H]inositol (1,4,5) trisphosphate specific binding in mouse cerebellar membrane fragments. Life Sciences. ,vol. 41, pp. 2863- 2868 ,(1987) , 10.1016/0024-3205(87)90433-4
Paul F. Worley, Jay M. Baraban, Jennifer S. Colvin, Solomon H. Snyder, Inositol trisphosphate receptor localization in brain: variable stoichiometry with protein kinase C. Nature. ,vol. 325, pp. 159- 161 ,(1987) , 10.1038/325159A0
Michael J Tiemeyer, Harvey S Singer, Juan C Troncoso, Linda C Cork, Joseph T Coyle, Donald L Price, None, Synaptic Neurochemical Alterations Associated with Neuronal Degeneration in an Inherited Cerebellar Ataxia of Gordon Setters Journal of Neuropathology and Experimental Neurology. ,vol. 43, pp. 580- 591 ,(1984) , 10.1097/00005072-198411000-00003
Brian Pearce, Martin Cambray-Deakin, Christine Morrow, Jill Grimble, Sean Murphy, Activation of muscarinic and of α1-adrenergic receptors on astrocytes results in the accumulation of inositol phosphates Journal of Neurochemistry. ,vol. 45, pp. 1534- 1540 ,(1985) , 10.1111/J.1471-4159.1985.TB07224.X