Balancing selection and heterogeneity across the classical human leukocyte antigen loci: a meta-analytic review of 497 population studies.

摘要: This paper presents a meta-analysis of high-resolution human leukocyte antigen (HLA) allele frequency data describing 497 population samples. Most the datasets were compiled from studies published in eight journals 1990 to 2007; additional came International Histocompatibility Workshops and AlleleFrequencies.net database. In all, these represent approximately 66,800 individuals throughout world, providing an opportunity observe trends that may not have been evident at time originally analyzed, especially with regard relative importance balancing selection among HLA loci. Population genetic measures distributions summarized across populations by locus geographic region. A role for maintaining much variation was confirmed. Further, breadth this allowed ranking loci, DQA1 HLA-C showing strongest DPB1 being compatible neutrality. Comparisons allelic spectra reported since indicate most alleles identified 2000 are very-low-frequency alleles. The literature-based allele-count data, as well maps summarizing each allele, available online.