Using HLA loci to inform ancestry and health in Polynesian and Maori populations

摘要: Human leukocyte antigens (HLA) are important genetic markers of tissue identity and accurately reflect ancestral history. The work reported in this paper provides a detailed description HLA polymorphism Polynesian Maori individuals relation to other populations. Our study concerns classes I II (N = 36) (N = 114) subjects genotyped at two digit resolution by New Zealand Blood Service Laboratory Auckland using polymerase chain reaction-sequence specific oligonucleotide PCR-SSP technologies. We have also compared our data with those from Austronesian-speaking Mongoloid Papuan-speaking Australoid populations order test previously published account the origin Proto-Polynesians via gender-biassed gene flow between these use principal coordinate analysis for purpose, arguing approach be superior tree-based methods, because factors associated population history admixture. general agreement earlier received wisdom on dual Proto-Polynesians. They show way which make-up is changing due intermarriage Europeans.