At the Center of Autophagy : Autophagosomes
作者： F. Reggiori , M. Mauthe
DOI: 10.1016/B978-0-12-394447-4.20021-7
关键词:
摘要: Autophagosomes are double-membrane sequestering vesicles that the hallmark of intracellular catabolic process called macroautophagy. They formed by orchestrated interplay AuTophaGy-related (ATG) proteins. The cargo molecules targeted autophagosomes ranges from long-lived proteins and superfluous or excess organelles to invading pathogens. finally fuse with lysosomes delivering sequestered material in interior these where it is degraded resident hydrolases. Autophagy represents a key survival mechanism because clears cytoplasm unwanted potentially toxic structures, central stage it.
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