The Role of Mitochondria in Atherosclerosis

摘要: Mitochondria are both sources and targets of reactive oxygen species, there is increasing evidence that mitochondrial dysfunction may be a significant mechanism by which cardiovascular risk factors lead to the formation vascular lesions. Recent studies have focused on role mitochondria could play in atherogenesis since important ROS. This further suggested theory postulates excess release ROS RNS from can contribute inflammatory reaction, leading development atherosclerotic Also, common encountered daily clinical practice involved this process adversely affecting function endothelial mitochondria, most unifying explaining atherogenic action major factors. The molecular mechanisms subsequent impairment will reviewed chapter.