Sharp-Wave Ripples in Primates Are Enhanced near Remembered Visual Objects

摘要: Summary The hippocampus plays an important role in memory for events that are distinct space and time. One of the strongest, most synchronous neural signals produced by is sharp-wave ripple (SWR), observed a variety mammalian species during offline behaviors, such as slow-wave sleep [1–3] quiescent waking pauses exploration [4–8], leading to long-standing widespread theories its contribution plasticity these inactive or immobile states [9–14]. Indeed, inactivity, hippocampal SWRs rodents appear support spatial long-term working [4, 15–23], but so far, they have not been linked primates. More recently, active, visual scene macaques [24], opening up possibility active-state ripples primate objects embedded scenes. By measuring search scene-contextualized objects, we found SWR rate increased with repeated presentations. Furthermore, gaze was more likely be near target object on than novel presentations, even after accounting overall differences location repetition. This proximity bias repetition occurred time detection remembered targets. increase likelihood suggests link between primates; specifically, may reflect part a mechanism supporting guidance based past experience.