1.129 – Engineering the Biophysical Properties of Basement Membranes into Biomaterials: Fabrication and Effects on Cell Behavior

摘要: Endothelial and epithelial cells receive biochemical biophysical cues from a specialized extracellular environment called the basement membrane (BM). Mimicking cues, including elastic modulus structural topography of BM, is one approach used in tissue engineering to fabricate biomaterials for regeneration. The properties many BMs present within tissues have been characterized, findings highlight that BM composed compliant protein matrix with nanofibrous texture. Researchers use various fabrication methods develop materials probe how scale controls cellular behavior. For example, studies demonstrated relevant nanotopography can elicit different cell responses (as measured by morphology, proliferation, migration, etc.) compared micron-scale topography. In addition, response physical dependent on multiple factors such as soluble type. These demonstrate are essential components be included design engineering.