Distinct temporal expression of 5-HT(1A) and 5-HT(2A) receptors on cerebellar granule cells in mice.

摘要: Serotonin plays an important role of controlling the physiology cerebellum. However, serotonin receptor expression has not been fully studied in developing We have recently shown that cerebellar granule cells transiently express 5-HT3 receptors. In present study, we investigate 5-HT1 and 5-HT2 receptors mouse cerebellum both during postnatal development juvenile mice. Here, show for first time 5-HT1A 5-HT2A are on with a distinct temporal pattern: expressed only 2 weeks, while persists until at least 8 weeks after birth. Because its prolonged pattern, investigated electrophysiological properties receptor. by promote stability reducing variability synaptic response, they modulate paired-pulse ratio parallel fibre–Purkinje cell synapse. Furthermore, pharmacological block enhances short-term plasticity thus novel function via cells.