Further studies on the erythrocyte uptake of lead in vitro in amyotrophic lateral sclerosis (ALS) patients and controls. Abnormal erythrocyte fragility in ALS.

摘要: Following our earlier observations on increased plasma concentrations of lead in amyotrophic lateral sclerosis (ALS), the erythrocyte uptake from has been studied vitro. Whole-blood ALS patients and controls was incubated after addition (0.6 mumol/l whole-blood) were repeatedly determined. Incubation continued until haemolysis developed. Fairly stable established at, average, 0.5-0.6 10-30 min persisted throughout incubation with no significant difference between ALS- control samples. Unexpectedly, it also observed that occurred significantly than Plateau levels concentration same order as present experiments have both samples previous technique, where dose added twice high, these plateau about 10 times higher those vivo controls. It is therefore suggested final by factors other improbable differences are associated degree red cells. The may instead be caused fragility erythrocytes, manifested occurrence experiments. observation cell is, however, interest a possible manifestation generalized membrane defect.