Amyotrophic Lateral Sclerosis: Recent Advances in Pathogenesis and Therapeutic Trials

摘要: • We reviewed the current status of pathogenesis and therapeutic trials in amyotrophic lateral sclerosis (ALS). Clinical studies have identified several rare but definable causes for apparent ALS. Certain clinical features previously considered unlikely to occur ALS are found on careful examination. Epidemiologic surveillance recent neurotoxic plant seeds used Guam shed light endemic Extensive analyses biochemical, metabolic, immunologic, viral, toxic factors provided provocative results requiring further studies. Reflecting some these hypotheses, been performed more vigorously than ever. Amyotrophic is now investigated at molecular genetic level. Human autopsy experimental animal expanded our understanding basic mechanisms involving motoneuronal degeneration. In future, we must continue a relentless search ALS, prospective define limits well-designed, controlled trials.