Formulation optimization and characterization of transdermal film of simvastatin by response surface methodology.
作者： Rabinarayan Parhi , Padilam Suresh
DOI: 10.1016/J.MSEC.2015.08.056
关键词:
摘要: Matrix type of simvastatin transdermal film (SSTF) was developed with poly(vinyl alcohol) (PVA) and eudragit RL100 (EG) using response surface methodology (RSM) to investigate combined effect the selected process variables like SS concentration, PVA:EG ratio dibutyl phthalate (DBT) concentration at different levels on dependent such as tensile strength flux, an aim optimize a suitable combination drug, polymer plasticizer ratio. The study reveals that DBT highest strength, while exhibited pronounced flux through abdominal skin rat. According Derringer's desirability prediction tool, composition optimized found be 2% SS, 2:1 40% DBT. Under these conditions, SSTF predicted value 11.871 MPa 43.569 μg/cm(2)/h, respectively. in vivo hypolipidemic conducted for 14 days hyperlipidemia induced Sprague-Dawley rats significant lowering blood lipid level. absence irritation indicates prepared safe well tolerated formulation. Thus, may serve alternative therapy oral dosage form SS.
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