SRC-2 orchestrates polygenic inputs for fine-tuning glucose homeostasis

摘要: Despite extensive efforts to understand the monogenic contributions perturbed glucose homeostasis, complexity of genetic events that fractionally contribute spectrum this pathology remain poorly understood. Proper maintenance homeostasis is central feature a constellation comorbidities define metabolic syndrome. The ability liver balance carbohydrate uptake and release during feeding-to-fasting transition essential regulation peripheral availability. coordinates expression gene programs control absorption, storage, secretion. Herein, we demonstrate Steroid Receptor Coactivator 2 (SRC-2) orchestrates hierarchy nutritionally responsive transcriptional complexes precisely modulate plasma Using DNA pull-down technology coupled with mass spectrometry, have identified SRC-2 as an indispensable integrator rate-limiting steps hepatic accretion. Collectively, these findings position major regulator polygenic inputs perhaps identify previously unappreciated model helps explain clinical dysregulation.