Modulation of Mouse Coagulation Gene Transcription following Acute In Vivo Delivery of Synthetic Small Interfering RNAs Targeting HNF4α and C/EBPα
作者： Huma Safdar , Ka Lei Cheung , Hans L. Vos , Frank J. Gonzalez , Pieter H. Reitsma
DOI: 10.1371/JOURNAL.PONE.0038104
关键词: Hepatocyte nuclear factors 、 Biology 、 Transcription factor 、 Transcriptional regulation 、 Regulation of gene expression 、 Molecular biology 、 Small interfering RNA 、 RNA 、 Gene knockdown 、 Messenger RNA 、 General Biochemistry, Genetics and Molecular Biology 、 General Agricultural and Biological Sciences 、 General Medicine
摘要: … levels of the control genes Pck1 and Fasn and a modest downregulation for coagulation genes … in vivo siRNA approach to rapidly reduce HNF4α and C/EBPα expression in mouse livers …
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