Mesolimbic dopaminergic system is involved in diurnal blood pressure regulation

摘要: Parkinson's disease (PD) patients with autonomic failure show no nocturnal decrease in blood pressure (BP). At present, it is not clear if this symptom attributable to the disturbance of dopaminergic (DA) system that responsible for PD. In present study, we determined mesolimbic DA involved diurnal profiles mean BP (MBP) by destroying A10 rats 6-hydroxydopamine. control rats, a dip MBP and heart rate (HR) occurs during light, is, resting period, analogous normal humans. This daytime HR was disturbed inducing lesion ventral tegmental area (VTA) neurons, although rhythms wake-sleep duration behavioral activity remained relatively intact. On basis evidence, absence PD attributed impairment system.