Midkine Is a Potential Therapeutic Target of Hepatocellular Carcinoma
作者： Li Cheng Dai , Xing Yao , Jing Zhong
DOI: 10.1007/978-94-007-4234-5_24
关键词:
摘要: Midkine (MK), a heparin-binding growth factor, has been demonstrated frequently and highly expressed in variety of human carcinomas, including hepatocellular carcinoma (HCC). There is mounting evidence indicating that MK plays significant role carcinogenesis-related activities, such as proliferation, migration, anti-apoptosis, mitogenesis, transformation, angiogenesis. Futhermore, siRNA, anti-sense oligonucleotides or antibody to yielded great effects anti-prolierative activities HCC cells. Therefore, appears be potential molecular target for therapy HCC.
springer.com
sci-hub.st 参考文章(49)
Garrett M. Brodeur, Jeffrey Milbrandt, Huaqing Zhao, Akira Nakagawara, Thomas F. Deuel, Takashi Muramatsu, Avital Cnaan, Differential Expression of Pleiotrophin and Midkine in Advanced Neuroblastomas Cancer Research. ,vol. 55, pp. 1792- 1797 ,(1995)
Ramon Alemany, Cristina Balagué, David T. Curiel, Replicative adenoviruses for cancer therapy Nature Biotechnology. ,vol. 18, pp. 723- 727 ,(2000) , 10.1038/77283
Hiroya Obama, Jun-ichiro Tsutsui, Masayuki Ozawa, Hiroki Yoshida, Yoshihiro Yoshida, Mitsuhiro Osame, Takashi Muramatsu, Midkine (MK) Expression in Extraembryonic Tissues, Amniotic Fluid, and Cerebrospinal Fluid during Mouse Embryogenesis Journal of Biochemistry. ,vol. 118, pp. 88- 93 ,(1995) , 10.1093/OXFORDJOURNALS.JBCHEM.A124896
Ragaa.H.M. Salama, Hisako Muramatsu, Kun Zou, Tatsuya Inui, Terutoshi Kimura, Takashi Muramatsu, Midkine binds to 37-kDa laminin binding protein precursor, leading to nuclear transport of the complex Experimental Cell Research. ,vol. 270, pp. 13- 20 ,(2001) , 10.1006/EXCR.2001.5341
Sejeong Shin, Byung-Je Sung, Yong-Soon Cho, Hyun-Ju Kim, Nam-Chul Ha, Jong-Ik Hwang, Chul-Woong Chung, Yong-Keun Jung, Byung-Ha Oh, An Anti-apoptotic Protein Human Survivin is a Direct Inhibitor of Caspase-3 and -7 Biochemistry. ,vol. 40, pp. 1117- 1123 ,(2001) , 10.1021/BI001603Q
Soichi Kojima, Hisako Muramatsu, Hiroshi Amanuma, Takashi Muramatsu, Midkine Enhances Fibrinolytic Activity of Bovine Endothelial Cells Journal of Biological Chemistry. ,vol. 270, pp. 9590- 9596 ,(1995) , 10.1074/JBC.270.16.9590
T. Misteli, Protein Dynamics: Implications for Nuclear Architecture and Gene Expression Science. ,vol. 291, pp. 843- 847 ,(2001) , 10.1126/SCIENCE.291.5505.843
Chaoying Yin, C. Michael Knudson, Stanley J. Korsmeyer, Terry Van Dyke, Bax suppresses tumorigenesis and stimulates apoptosis in vivo Nature. ,vol. 385, pp. 637- 640 ,(1997) , 10.1038/385637A0
Li-cheng DAI, Xiang WANG, Xing YAO, Yong-liang LU, Jin-liang PING, Jian-fang HE, Antisense oligonucleotides targeting midkine induced apoptosis and increased chemosensitivity in hepatocellular carcinoma cells Acta Pharmacologica Sinica. ,vol. 27, pp. 1630- 1636 ,(2006) , 10.1111/J.1745-7254.2006.00459.X
Li-cheng DAI, Xiang WANG, Xing YAO, Li-shan MIN, Jin-liang PING, Jian-fang HE, Antisense oligonucleotides targeting midkine inhibit tumor growth in an in situ human hepatocellular carcinoma model Acta Pharmacologica Sinica. ,vol. 28, pp. 453- 458 ,(2007) , 10.1111/J.1745-7254.2007.00532.X