An Anti-apoptotic Protein Human Survivin is a Direct Inhibitor of Caspase-3 and -7

作者: Sejeong Shin , Byung-Je Sung , Yong-Soon Cho , Hyun-Ju Kim , Nam-Chul Ha

DOI: 10.1021/BI001603Q

关键词:

摘要: … inhibitor has been unclear due to the difficulties with obtaining correctly folded survivin and finding the right conditions for inhibition assay. … by more significant conformational changes of …

参考文章(1)
Laurent Chantalat, Dimitrios A. Skoufias, Jean-Philippe Kleman, Barbara Jung, Otto Dideberg, Robert L. Margolis, Crystal Structure of Human Survivin Reveals a Bow Tie–Shaped Dimer with Two Unusual α-Helical Extensions Molecular Cell. ,vol. 6, pp. 183- 189 ,(2000) , 10.1016/S1097-2765(05)00020-1