Apoptosis in Colorectal Tumorigenesis and Chemotherapy
作者： Shi Yu Yang , Kevin M. Sales , Marc C. Winslet
DOI: 10.1007/978-1-4020-9597-9_4
关键词:
摘要: Colorectal cancer is the second most common in western world. At least 40% of colorectal patients develop metastases; chemotherapy alone or combination with radiotherapy usually used as adjuvant treatment for advanced disease. Unfortunately treatments are often ineffective due to development resistance. A major contributor chemo-resistance inhibition avoidance apoptosis. This chapter reviews genetic mutations tumorigenesis; alterations apoptosis progression; and relationship between apoptotic changes. The factors which affect regulate evaluated. dysfunction different pathways through cells resistance chemotherapies discussed. Finally potential molecular targets therapeutic strategies designed against these proposed.
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