Human milk factors and atopy in early childhood

摘要: Background: The protective effect of breast milk against atopic manifestations in infancy, i. e. eczema and food allergy, has been controversial for the last decades. Differences composition human could explain these controversies.Aims: To investigate antibodies, such as lgE, total S-IgA antibodies inhalant allergens (B-lactoglobulin, ovalbumin cat allergen) from non mothers. study nucleotide, polyamine polyunsaturated fatty acid (PUFA) composition. Furthermore, factors maternal were related to development allergic disease children during first 18 months life.Methods: One hundred twenty (120) followed at 3, 6, 12 age. Blood samples obtained birth 3 months. Skin prick tests petformed diseases was assessed children. Breast collected their mothers monthly dming lactation period. Total IgE measured by RIA ELISA. Milk nucleotides polyamines HPLC PUFA gas chromatography.Results: levels similar colostrum mothers, were, however, lower mature than Levels foods cat, two groups period, except low anti-OVA S-lgA Nucleotide Low putrescine spermine found mothers.Low LA, LNA, n-6 LCP n-3 particularly higher LAILNA AA!EPA ratios one month lactation. Correlations between individual observed These correlations absent individuals, indicating a disturbed metabolism. differences less obvious serum phospholipids newboms.Total well nucleotide Lower EPA transitional EPA, DPA DHA (p<0.05 all) compared n-6/total AA/EPA both within acids not atopy In contrast, C20:4 correlated most only children.The PUP A similar, C22:4 C22:5 both) ratio phospho1ipids former group (p<0.05). Changes reflected changes phospholipids, PUPA. related, children, while this case children.Conclusion: anti-QV S-IgA, milk. atopy. Human antibody Neither anergic atopy, high infants allergy PUPA influenced findings are suggested be partly 8-6 desaturase dysfunction individuals.