Polyunsaturated n-3 fatty acids and the development of atopic disease.

摘要: The relationship between polyunsaturated long-chain fatty acids and atopy has been discussed for decades. Higher levels of the essential linoleic acid α-linolenic lower their longer metabolites in plasma phospholipids atopic as compared to nonatopic individuals have reported by several, but not all, studies. Largely similar findings studies cell membranes from immunological cells atopics nonatopics despite differences methodology, study groups, definitions atopy. An imbalance metabolism n−6 acids, particularly arachidonic dihomo-γ-linolenic acid, leading an inappropriate synthesis prostaglandin (PG) E2 PGE1 was hypothesized early on corroborated. composition human milk is dependent time lactation only during a breast meal also day period lactation. This explains discrepancies regarding disease mother. Prospective show disturbances both n−3 mothers. Only related development children, however. A eicosapentaenoic (20∶5 n−3), hypothesized.