Efficient and recyclable Cu2(BPDC)2(DABCO)-catalyzed direct amination of activated sp3 C H bonds by N–H heterocycles

摘要: Abstract A metal-organic framework Cu 2 (BPDC) (DABCO) was successfully synthesized and employed as an efficient heterogeneous catalyst for the direct C N cross-coupling reaction via sp 3 bond activation between N–H heterocycles amides. Kinetic investigation thoroughly conducted. The optimal conditions involve use of (3%), di- tert -butyl peroxide oxidant (2 equivalents) in chlorobenzene solvent at 120 °C 2 h. offered higher catalytic activity than that other Cu-MOFs such (BPY), (BTC) (BDC) (DABCO), several common copper salts CuCl, CuBr, CuI, Cu(NO ) , CuSO 4 . To investigate mechanism, poisoning experiments reactions with added radical scavengers were Furthermore, could be recovered reused times without much decline yield.