Chapter 7 – Aluminum and Gene Transcription in the Mammalian Central Nervous System — Implications for Alzheimer's Disease

摘要: Aluminum has been repeatedly implicated in the etiopathology of several human neurodegenerative disorders including Alzheimer's disease. Due largely to extensive euchromatization normal brain cell neuronal nuclei and their high intrinsic rate transcription, one prime target for aluminum appears be within nucleic acid compartments central nervous system. Generally, positive charge density (Z2/r = 17.65) acts as a pervasive repressor demodulator neural activity. This chapter will review our current knowledge concerning genotoxic 'dementing' cation, particularly it applies neural-specific gene transcription factors brain.