Teniposide for Brain Metastases of Small-Cell Lung Cancer: A Phase II Study
作者： P E Postmus , E F Smit , H Haaxma-Reiche , N van Zandwijk , A Ardizzoni
DOI: 10.1200/JCO.1995.13.3.660
关键词:
摘要: PURPOSEHere we report the results of a phase II study teniposide, one most active drugs against small-cell lung cancer (SCLC), in patients with brain metastases.PATIENTS AND METHODSPatients SCLC who presented metastases at diagnosis (n = 11) or during follow-up evaluation after treatment 69) were treated teniposide dose 150 mg/m2 intravenously on days 1, 3, and 5 3-week intervals an outpatient setting. Response was evaluated by computed tomography (CT) two, six, 12 courses.RESULTSIn 26 80 assessable patients, intracranial response seen, rate 33% (95% confidence interval, 22% to 44%). The median duration 5.4 months for complete (CR) 4.2 partial (PR). Patients required corticosteroids peritumoral edema had significantly lower than did not receive corticosteroids. Neurologic function th...
narcis.nl参考文章(33)
P.J. Hoskin, J.R. Yarnold, B. Robinson, I.E. Smith, C.F. Lucas, H.T. Ford, Morbidity of cranial relapse in small cell lung cancer and the impact of radiation therapy. Cancer treatment reports. ,vol. 70, pp. 565- 570 ,(1986)
John D Minna, A. V. Johnston, B. E. Fossieck, P. J. Creaven, M. H. Cohen, O. S. Selawry, C. L. Williams, L. E. Broder, Intensive chemotherapy of small cell bronchogenic carcinoma. Cancer treatment reports. ,vol. 61, pp. 349- 354 ,(1977)
David R. Cox, Regression Models and Life-Tables Springer Series in Statistics. ,vol. 34, pp. 527- 541 ,(1992) , 10.1007/978-1-4612-4380-9_37
Paul E.G. Kristjansen, Heine H. Hansen, Brain metastases from small cell lung cancer treated with combination chemotherapy. European Journal of Cancer and Clinical Oncology. ,vol. 24, pp. 545- 549 ,(1988) , 10.1016/S0277-5379(98)90035-9
John L. Nugent, Paul A. Bunn, Mary J. Matthews, Daniel C. Ihde, Martin H. Cohen, Adi Gazdar, John D. Minna, CNS metastases in small cell bronchogenic carcinoma: increasing frequency and changing pattern with lengthening survival. Cancer. ,vol. 44, pp. 1885- 1893 ,(1979) , 10.1002/1097-0142(197911)44:5<1885::AID-CNCR2820440550>3.0.CO;2-F
Stephen J. Newman, Heine H. Hansen, Frequency, diagnosis, and treatment of brain metastases in 247 consecutive patients with bronchogenic carcinoma Cancer. ,vol. 33, pp. 492- 496 ,(1974) , 10.1002/1097-0142(197402)33:2<492::AID-CNCR2820330225>3.0.CO;2-O
LEONARD GIANNONE, Favorable Prognosis of Brain Metastases in Small Cell Lung Cancer Annals of Internal Medicine. ,vol. 106, pp. 386- 389 ,(1987) , 10.7326/0003-4819-106-3-386
Robert J. Baglan, James E. Marks, Comparison of symptomatic and prophylactic irradiation of brain metastases from oat cell carcinoma of the lung Cancer. ,vol. 47, pp. 41- 45 ,(1981) , 10.1002/1097-0142(19810101)47:1<41::AID-CNCR2820470109>3.0.CO;2-M
Heine H. Hansen, Oleg S. Selawry, Richard Simon, David T. Carr, C. E. van Wyk, R. D. Tucker, Rossall Sealy, Combination chemotherapy of advanced lung cancer.A randomized trial Cancer. ,vol. 38, pp. 2201- 2207 ,(1976) , 10.1002/1097-0142(197612)38:6<2201::AID-CNCR2820380602>3.0.CO;2-4
Hanny Haaxma-Reiche, Henk H. Berendsen, Piet E. Postmus, PODOPHYLLOTOXINS FOR BRAIN METASTASES OF SMALL CELL LUNG-CANCER Journal of Neuro-oncology. ,vol. 6, pp. 231- 232 ,(1988) , 10.1007/BF00163706