Brain metastases from small cell lung cancer treated with combination chemotherapy.

作者: Paul E.G. Kristjansen , Heine H. Hansen

DOI: 10.1016/S0277-5379(98)90035-9

关键词: CyclophosphamideRespiratory diseaseTeniposideSurgeryMedicineCombination chemotherapyEtoposideLomustineMetastasisRadiologyVincristine

摘要: Ten patients with metastatic small cell lung cancer (SCLC) in the brain, shown by CT scan at time of diagnosis, were treated systemic combination chemotherapy. Repeated scans performed every 4 weeks. Seven evaluable, since three died during first 2-3 Significant responses on as well neurologic improvement demonstrated all evaluable patients. Four seven obtained a complete response while had partial remissions. The impact this observation overall treatment strategies SCLC has further to be defined.

参考文章(19)
Shechtman L, Finkelstein T, Fitzpatrick A, Comis R, Panasci L, Fandrich S, Ginsberg S, Kirshner J, Reich S, Systemic chemotherapy for a primary germ cell tumor of the brain: a pharmacokinetic study. Cancer treatment reports. ,vol. 65, pp. 477- ,(1981)
HAGOP KANTARJIAN, PETER A.M. FARHA, GARY SPITZER, WILLIAM K. MURPHY, MANUEL VALDIVIESO, Systemic combination chemotherapy as primary treatment of brain metastasis from lung cancer. Southern Medical Journal. ,vol. 77, pp. 426- 430 ,(1984) , 10.1097/00007611-198404000-00005
Kell Østerlind, Prognostic Factors in Small Cell Lung Cancer: An Analysis of 874 Consecutive Patients Lung Cancer: Basic and Clinical Aspects. pp. 129- 152 ,(1986) , 10.1007/978-1-4613-2295-5_8
Edward A Neuwelt, Suellen A Dahlborg, Chemotherapy administered in conjunction with osmotic blood-brain barrier modification in patients with brain metastases. Journal of Neuro-oncology. ,vol. 4, pp. 195- 207 ,(1987) , 10.1007/BF00150611
PlETER E POSTMUS, HANNY HAAXMA-REICHE, LOUK M VENCKEN, AAFKE F MEINESZ, DIRK TH SLEIJFER, NANNO H MULDER, Remission of Brain Metastases from Small-Cell Lung Cancer After High-Dose Chemotherapy Annals of Internal Medicine. ,vol. 101, pp. 717- 717 ,(1984) , 10.7326/0003-4819-101-5-717
J. S. Gordon Rustin, Edward S. Newlands, Kenneth D. Bagshawe, H. J. RICHARD Begent, S. Michael Crawford, Successful management of metastatic and primary germ cell tumors in the brain. Cancer. ,vol. 57, pp. 2108- 2113 ,(1986) , 10.1002/1097-0142(19860601)57:11<2108::AID-CNCR2820571103>3.0.CO;2-Z
Fred R. Hirsch, Olaf B. Paulson, Heine H. Hansen, S. Olesen Larsen, Intracranial metastases in small cell carcinoma of the lung prognostic aspects Cancer. ,vol. 51, pp. 529- 533 ,(1983) , 10.1002/1097-0142(19830201)51:3<529::AID-CNCR2820510327>3.0.CO;2-0
Oscar Auerbach, Histological Typing Of Lung Tumors The Annals of Thoracic Surgery. ,vol. 5, pp. 95- ,(1968) , 10.1016/S0003-4975(10)66314-X
Nigel H. Greig, Optimizing drug delivery to brain tumors. Cancer Treatment Reviews. ,vol. 14, pp. 1- 28 ,(1987) , 10.1016/0305-7372(87)90048-X